Job Description

Preventive Medicine is a venture‑backed biotech startup developing next‑generation reproductive‑genetics platforms to eliminate severe genetic disease before birth.

As one of the first scientific hires , you will help define our technical roadmap, build our R&D culture from the ground up, and influence the long‑term direction of the company. We are seeking an entrepreneurial Scientist to design, build, and evaluate advanced adenine & cytosine base editors (ABE, CBE) and RT editors . Partnering directly with the co‑founders, you will take new editor concepts from the bench to IND‑enabling studies while laying the foundation of our research organization.

Key Responsibilities

• Establish the editor‑engineering pipeline – Optimize ABE/CBE/RT‑editing architectures for potency, specificity, and manufacturability
• High‑throughput cloning & screening workflows (automated assembly, pooled libraries, functional reporters) and streamline data capture
• Develop quantitative assays for on‑ and off‑target analysis using cutting‑edge sequencing and bioinformatics platforms.
• Drive preclinical translation in relevant cell models and preclinical species
• Recruit, mentor, and lead a small team of research associates and scientists;
• Communicate program progress through protocols, data packages, and presentations to investors, advisors, and regulatory consultants.

Requirements

Minimum Qualifications

• 5+ years hands‑on experience engineering CRISPR base or prime editors in mammalian systems – demonstrated impact matters more than formal credentials.
• Proficiency with NGS library preparation & analysis (e.g., CRISPResso2, CRISPR‑RGEN Tools) and basic Python/R scripting for data processing.
• Proven track record of leading complex projects and publishing or patenting influential work.
• Strong work ethic, scientific rigor, and high integrity.

Preferred qualifications

• Familiarity with regulatory standards and assays relevant to gene‑editing therapeutics
• Experience generating and using RNPs and mRNA for gene editing, including delivery via electroporation or nanoparticles.
• Prior startup or small‑team experience in fast‑moving environments.
• Comfort with automation (liquid handlers, LIMS) and/or single‑cell genotyping/transcriptomics.

Benefits

• Competitive salary plus meaningful equity —share in the company’s upside.
• Comprehensive health, dental, and vision coverage.
• 401(k) with company match.

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